BDBM202028 (e)-(1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-2-yl)vinyl)pyridin-2-yl)pyrrolidin-3-yl)methanol::US9540384, 25

SMILES CN(C)c1nc(\C=C\c2cccc(n2)N2CCC(CO)C2)nc2ccc(Cl)cc12

InChI Key InChIKey=MAMFOHPRHXLJLC-VQHVLOKHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 202028   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM202028((e)-(1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin...)
Affinity DataIC50:  220nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent