BDBM204718 4-chloro-3-(8-chloro-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-phenol::US9540379, 107

SMILES Cc1nc2ccc(Cl)cc2n2c(nnc12)-c1cc(O)ccc1Cl

InChI Key InChIKey=HXCMWAGIKQHTTN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 204718   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204718(4-chloro-3-(8-chloro-4-methyl-[1,2,4]triazolo[4,3-...)
Affinity DataIC50:  2nMAssay Description:The DNA encoding PDE2A (NM002599) was cloned and the gene was inserted in the baculovirus and the enzyme-protein expressed in SF21-cells. The enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204718(4-chloro-3-(8-chloro-4-methyl-[1,2,4]triazolo[4,3-...)
Affinity DataIC50:  13nMAssay Description:The DNA of PDE10A1 (AB 020593, 2340 bp) was synthesized and cloned into the vector pCR4. TOPO (Entelechon GmbH, Regensburg, Germany). The gene was th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent