BDBM20488 (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide::SB-366791

SMILES COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1

InChI Key InChIKey=RYAMDQKWNKKFHD-JXMROGBWSA-N

Data  6 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 20488   

LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataEC50:  20nMpH: 7.2 T: 2°CAssay Description:One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...More data for this Ligand-Target Pair
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in CHO cells assessed as inhibition of capsiacin-induced Ca2+ flux by Fluo-3 dye bas...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataIC50:  3.70E+3nMAssay Description:Antagonist activity at rat TRPV1 expressed in human HEK293 cells assessed as inhibition of capsaicin-induced influx by measuring intracellular calciu...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TRPM8 expressed in HEK293T cells assessed as blocked of menthol-activated current by whole cell patch clamp electrophysiology rel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 1(Mus musculus)
Peking University

Curated by ChEMBL
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of mouse TRPM1 expressed in HEK293T cells assessed as blocked of capsaicin-activated current at 10 uM by whole cell patch clamp electrophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in CHO cells assessed as inhibition of capsiacin-induced Ca2+ flux by Fluo-3 dye bas...More data for this Ligand-Target Pair