BDBM207606 US10501467, Example 51::US9260440, 51::US9617273, Example 51

SMILES CC(C)(C)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O

InChI Key InChIKey=HTRPLWGQNMXGRD-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 207606   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  11nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  1.30nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  660nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  1.10E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  6.60E+5nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  6.60E+5nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  1.10E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  1.30E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM207606(US10501467, Example 51 | US9260440, 51 | US9617273...)
Affinity DataIC50:  1.30E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent