BDBM209109 US9266877, 55
SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2c(F)cccc2F)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
InChI Key InChIKey=VNKXQOCVVJIDLY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 209109
Affinity DataKi: 18nM ΔG°: -10.6kcal/moleT: 2°CAssay Description:The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...More data for this Ligand-Target Pair
Affinity DataEC50: 317nMAssay Description:The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...More data for this Ligand-Target Pair