BDBM21435 N-Benylpiperazine derivative, 23c::N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-{4-[(2-methoxyphenyl)methyl]piperazin-1-yl}benzamide

SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=BMFIKSDWRTVGGF-SSEXGKCCSA-N

Data  2 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 21435   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21435(N-Benylpiperazine derivative, 23c | N-[(4-{[(2R)-4...)
Affinity DataKi: <0.5nM IC50:  80nM EC50:  390nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21435(N-Benylpiperazine derivative, 23c | N-[(4-{[(2R)-4...)
Affinity DataKi:  3.20nM EC50:  950nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21435(N-Benylpiperazine derivative, 23c | N-[(4-{[(2R)-4...)
Affinity DataEC50:  390nMAssay Description:Inhibition of Bcl-XLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed