BDBM21674 (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid::CDCA::CHENODIOL::Chenodeoxycholic Acid::US10208081, CDCA
SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O
InChI Key InChIKey=RUDATBOHQWOJDD-BSWAIDMHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 21674
Affinity DataEC50: 2.10E+4nMAssay Description:Agonist activity at human GST-fused FXR LBD assessed as coactivator interaction with receptor ligand binding domain by Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.66E+3nMAssay Description:Binding affinity for Farnesoid X Receptor (FXR)More data for this Ligand-Target Pair
Affinity DataEC50: 8.66E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+3nMAssay Description:Effective concentration for recruitment of SRC-1 LxxLL-containing peptide to human Farnesoid X receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+4nMAssay Description:Activation of human farnesoid X receptor; range is 10-30More data for this Ligand-Target Pair
Affinity DataEC50: 8.66E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.03E+4nMAssay Description:Agonist activity at wild type TGR5 (unknown origin)More data for this Ligand-Target Pair