BDBM217082 US9302989, 377

SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2CCCCc12)N1Cc2ccccc2C1

InChI Key InChIKey=LUJABRZNRKRZRI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 217082   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM217082(US9302989, 377)
Affinity DataKi:  19.5nMAssay Description:HTRF assay: This assay used the CisBio HTRF KinEASE kit (kit 62ST2PEZ) and the kinase reaction containing 0.2 uM biotinylated substrate peptide (S2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM217082(US9302989, 377)
Affinity DataKi:  20nMAssay Description:Inhibition of ROCK2 (unknown origin) using S6-peptide as substrate in presence of [33P]-ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM217082(US9302989, 377)
Affinity DataIC50:  105nMAssay Description:Inhibition of recombinant human C-terminally-His tagged NAMPT incubated for 2 to 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM217082(US9302989, 377)
Affinity DataIC50:  105nMpH: 7.5Assay Description:Probe 1:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent