BDBM22369 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one::CHEMBL122::MK 0966::Rofecoxib::US11478464, Compound Rofecoxib::US11786535, Compound Rofecoxib
SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1
InChI Key InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 168 hits for monomerid = 22369
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 500nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >1.50E+4nMAssay Description:In vitro inhibitory activity against human whole cells Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.90E+4nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.88E+4nMAssay Description:The compound was evaluated for its inhibitory activity against COX- 1.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >5.00E+5nMAssay Description:In vitro inhibitory activity of the compound against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 1 in human whole blood assay as TXB2 generationMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:In vitro inhibition against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 830nMAssay Description:Tested in vitro for inhibition of cyclooxygenase-2 in human blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 280nMAssay Description:In vitro inhibition of PGE-2 generation by LPS-stimulated monocytes isolated from human blood.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.83E+4nMAssay Description:Tested in vitro for inhibition of cyclooxygenase-1 in human blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+4nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 1 using monocytes-like cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >5.00E+5nMAssay Description:In vitro inhibitory concentration of compound required to inhibit Prostaglandin G/H synthase 1 enzyme was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:In vitro inhibitory activity of the compound against prostaglandin G/H synthase 1 from ovineMore data for this Ligand-Target Pair
Affinity DataIC50: >430nMAssay Description:In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovineMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:In vitro inhibitory activity of the compound against prostaglandin G/H synthase 1 from ovineMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 500nMAssay Description:Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against ovine Cyclooxygenase-1More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of purified ovine COX-1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of purified ovine COX-1 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant COX-2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human recombinant COX-2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 300nMAssay Description:Compound was tested for the inhibition of human Prostaglandin G/H synthase 2 (COX-2) in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:Compound was tested for the inhibition of recombinant human Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 4.00E+4nMAssay Description:Compound was tested for the inhibition of human Prostaglandin G/H synthase 1 (COX-1) in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 2.87E+4nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 1 activity was evaluated in human whole blood as TXB2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 4.00E+4nMAssay Description:Compound was evaluated for inhibition concentration of prostaglandin G/H synthase 1 in human bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition concentration against cyclooxygenase-1 (COX-1) in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human cyclooxygenase-1 expressed in COS cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 4.00E+4nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibitory concentration against Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 340nMAssay Description:Inhibitory concentration against Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibitory concentration against Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 6.20E+4nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 1 (COX-1) in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hrMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 20nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Adis International
Curated by PDSP Ki Database
Adis International
Curated by PDSP Ki Database
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 500nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair