BDBM231252 US10092556, Comparative Example 6::US9346787, Comparative Example 6

SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2C#N)n[nH]1

InChI Key InChIKey=CTWASZOPAJRLED-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 231252   

TargetAurora kinase A(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US10092556, Comparative Example 6 | US9346787, Com...)
Affinity DataIC50:  220nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US10092556, Comparative Example 6 | US9346787, Com...)
Affinity DataIC50:  320nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US10092556, Comparative Example 6 | US9346787, Com...)
Affinity DataIC50:  220nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US10092556, Comparative Example 6 | US9346787, Com...)
Affinity DataIC50:  320nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent