BDBM239755 Roche-Dataset for PDE10A, Compound 359::US9394311, 38

SMILES Cc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12

InChI Key InChIKey=NCSCZUVPQAFJGQ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 239755   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM239755(Roche-Dataset for PDE10A, Compound 359 | US9394311...)
Affinity DataIC50:  0.280nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM239755(Roche-Dataset for PDE10A, Compound 359 | US9394311...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full-length recombinant human PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM239755(Roche-Dataset for PDE10A, Compound 359 | US9394311...)
Affinity DataIC50:  0.280nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB