BDBM246867 4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrrol-1- yl]propyl}piperazin- 1-yl)carbonyl]-3- fluorobenzonitrile::US10053465, 6::US10065963, Compound 6::US10125150, Example 6::US10336759, # 6::US10479803, Example 6::US10519163, Example 6::US10675284, Example 6::US11084822, Example 6::US11130767, # 6::US11136326, Example 6::US11304949, Compound 9::US11324749, Comp. No. 9::US11406640, Comp. No. 9::US11596632, Comp. No. 9::US20240058343, Compound 9::US9732097, Example 6

SMILES Fc1cc(ccc1C(=O)N1CCN(CC(CC#N)n2ccc(c2)-c2ncnc3[nH]ccc23)CC1)C#N

InChI Key

Data  29 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 246867   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246867(4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-...)
Affinity DataIC50: <10nMAssay Description:JAK1 pathway inhibitors that can be used for the treatment of cytokine-related diseases or disorders are tested for inhibitory activity of JAK target...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent