BDBM247045 2-((1R,3aR,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(2'- methoxy-[3,3'- bipyridin]-6- yl)vinyl)-1,6- dimethyl-3- oxooctahydro- isobenzofuran- 3a-yl)acetamide::US9701669, 16

SMILES COc1ncccc1-c1ccc(\C=C\[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@]3(CC(N)=O)CC(F)(F)[C@H]2C)nc1

InChI Key InChIKey=KQUSKRRSHXVUMC-AMPNWBNPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 247045   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247045(2-((1R,3aR,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(2&...)
Affinity DataIC50:  2.59E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase MARK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247045(2-((1R,3aR,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(2&...)
Affinity DataIC50:  104nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent