BDBM247206 US10513524, Compound (P4)::US11608342, Compound (P4)::US9434733, 2-[[3-[(4-fluorophenyl)methoxy]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-[(4-fluorophenyl)methoxy]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

SMILES Fc1ccc(COC2CN(Cc3nn4c(ncc4c(=O)[nH]3)C3CCOCC3)C2)cc1

InChI Key InChIKey=QEJJXMNBAFWGJK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 247206   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  10nMT: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  10nMpH: 7.6 T: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  10nMpH: 7.6 T: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  1.01E+3nMAssay Description:PDE1 assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 (sufficient to con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  1.01E+3nMAssay Description:PDE1 assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 (sufficient to con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  10nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM247206(US10513524, Compound (P4) | US11608342, Compound (...)
Affinity DataIC50:  10nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent