BDBM247807 US10112931, Example 411::US9434719, 411 as TFA salt::US9688672, Example 411

SMILES CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1

InChI Key InChIKey=NOOITAIFTJACTE-VBCZDQSUSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 247807   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM247807(US10112931, Example 411 | US9434719, 411 as TFA sa...)
Affinity DataIC50:  756nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM247807(US10112931, Example 411 | US9434719, 411 as TFA sa...)
Affinity DataIC50:  1.60E+3nMpH: 7.4 T: 2°CAssay Description:The biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent