BDBM250050 US10005782, Compound 172::US9447106, 172::US9556188, Compound 172

SMILES COc1cc(ccc1Oc1ccccc1)-c1nn2C(CCNc2c1C(N)=O)C1CCN(CC1)C(=O)C=C

InChI Key InChIKey=UGBDLAMFDOZLBT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 250050   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM250050(US10005782, Compound 172 | US9447106, 172 | US9556...)
Affinity DataIC50:  1.10nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM250050(US10005782, Compound 172 | US9447106, 172 | US9556...)
Affinity DataIC50:  1.10nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))TBA
LigandPNGBDBM250050(US10005782, Compound 172 | US9447106, 172 | US9556...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM250050(US10005782, Compound 172 | US9447106, 172 | US9556...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM250050(US10005782, Compound 172 | US9447106, 172 | US9556...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM250050(US10005782, Compound 172 | US9447106, 172 | US9556...)
Affinity DataIC50:  1.10nMAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent