BDBM25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5
SMILES CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O
InChI Key InChIKey=XQVVPGYIWAGRNI-JOCHJYFZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 25121
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant full length human PLK1 using casein as substrate incubated for 40 mins in the presence of [gamma33P]ATP at Km concentration...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human PLK2 (65 to 409 resiudes) using casein as substrate incubated for 40 mins in the presence of [gamma33P]ATP at Km conc...More data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Binding affinity to His6/TEV fused recombinant human BRD4 expressed in bacteria assessed as dissociation constant by isothermal titration calorimetry...More data for this Ligand-Target Pair