BDBM251575 US9452998, Table 4 Compound 5
SMILES COc1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC(N)CC1
InChI Key InChIKey=FVAXCXHKGMJCLC-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 251575
Affinity DataIC50: 0.190nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMpH: 7.5Assay Description:For comparison between certain PKC inhibitors of the present application and structurally comparable PIM kinase inhibitors, the activity of PIM2 was ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair