BDBM251576 US9452998, Table 4 Compound 6
SMILES Nc1ncc(nc1C(=O)Nc1cnccc1N1CCNCC1)-c1ccccc1F
InChI Key InChIKey=CEUSLGXUKGZQEI-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 251576
Affinity DataIC50: 0.800nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Affinity DataIC50: 78nMpH: 7.5Assay Description:For comparison between certain PKC inhibitors of the present application and structurally comparable PIM kinase inhibitors, the activity of PIM2 was ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair