BDBM25298 (1-hydroxy-1-phosphonoheptyl)phosphonic acid::CHEMBL55264::bisphosphonate, 10

SMILES CCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=IJEGNOYPWRBKAE-UHFFFAOYSA-N

Data  4 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 25298   

TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataKi:  240nMAssay Description:Inhibitory concentration of the compound against Trypanosoma brucei farnesyl pyrophosphate synthase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl diphosphate synthase(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataKi:  400nMAssay Description:Inhibition of Trypanosoma cruzi FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataKi:  400nMAssay Description:Inhibition of trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataKi:  560nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  5.88E+3nMAssay Description:Inhibitory activity against Leishmania major Farnesyl diphosphate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl diphosphate synthase(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of Trypanosoma cruzi FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibitory concentration of the compound against Trypanosoma brucei farnesyl pyrophosphate synthase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  5.89E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  1.12E+4nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed