BDBM253138 US9458171, 100::US9458171, 98::US9458171, 99

SMILES OC(=O)[C@H]1CC[C@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=AVHWMAVUUHFRKE-SRGWNRLKSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 253138   

TargetNuclear receptor ROR-gamma [262-507](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM253138(US9458171, 100 | US9458171, 98 | US9458171, 99)
Affinity DataIC50:  545nMT: 2°CAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [262-507](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM253138(US9458171, 100 | US9458171, 98 | US9458171, 99)
Affinity DataIC50:  59nMT: 2°CAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253138(US9458171, 100 | US9458171, 98 | US9458171, 99)
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at LXRalpha (unknown origin) expressed in African green monkey CV1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253138(US9458171, 100 | US9458171, 98 | US9458171, 99)
Affinity DataEC50:  4.23E+3nMAssay Description:Inverse agonist activity at GAL4-fused RORgammat LBD (267 to 516 residues) (unknown origin) expressed in human Jurkat cells measured after 18 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253138(US9458171, 100 | US9458171, 98 | US9458171, 99)
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at LXRbeta (unknown origin) expressed in African green monkey CV1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma [262-507](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM253138(US9458171, 100 | US9458171, 98 | US9458171, 99)
Affinity DataIC50:  758nMT: 2°CAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent