BDBM255740 US9475815, WO 2007/61737: 5::US9598416, Example 5 W 2007/061737

SMILES Cc1ccc2[nH]c(cc2c1)-c1nc(C2CCC2)n2ccnc(N)c12

InChI Key InChIKey=PJEKXBMIYGCRBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 255740   

TargetFibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P(Homo sapiens (Human))
Bayer Intelletual Property

US Patent
LigandPNGBDBM255740(US9475815, WO 2007/61737: 5 | US9598416, Example 5...)
Affinity DataIC50:  500nMpH: 7.0 T: 2°CAssay Description:A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM255740(US9475815, WO 2007/61737: 5 | US9598416, Example 5...)
Affinity DataIC50:  250nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM255740(US9475815, WO 2007/61737: 5 | US9598416, Example 5...)
Affinity DataIC50:  500nMAssay Description:Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3 [397-806]/Glutathione S-transferase P(Homo sapiens (Human))
Bayer Intelletual Property

US Patent
LigandPNGBDBM255740(US9475815, WO 2007/61737: 5 | US9598416, Example 5...)
Affinity DataIC50:  250nMpH: 7.0 T: 2°CAssay Description:A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent