BDBM258323 US9493485, 9-164

SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F

InChI Key InChIKey=FARQUNPWROAOKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258323   

TargetBeta-secretase 1(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258323(US9493485, 9-164)
Affinity DataIC50:  27.5nMpH: 7.0Assay Description:BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258323(US9493485, 9-164)
Affinity DataIC50: >3.00E+4nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258323(US9493485, 9-164)
Affinity DataIC50:  464nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent