BDBM258578 US10633384, Example 12.40::US9493486, 12.40

SMILES Fc1cc(COC(=O)N2CCC3(CN(C3)C(=O)C3CCc4nn[nH]c4C3)CC2)ccc1OCC(F)(F)F

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 258578   

TargetAtaxin-2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM258578(US10633384, Example 12.40 | US9493486, 12.40)
Affinity DataIC50:  2.5nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM258578(US10633384, Example 12.40 | US9493486, 12.40)
Affinity DataIC50:  2.5nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent