BDBM259064 US9499502, 9ed-a::US9499502, 9ed-b
SMILES C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
InChI Key InChIKey=PLCDXUBBYUCKTP-GOTSBHOMSA-N
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 259064
Affinity DataKi: 1.60nM ΔG°: -12.2kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
Affinity DataKi: <10nM ΔG°: <-11.1kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
Affinity DataKi: <10nM ΔG°: <-11.1kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
Affinity DataKi: 15.1nM ΔG°: -10.8kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair