BDBM259133 US9499502, 27ab
SMILES C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1nnco1
InChI Key InChIKey=RNIVXENTTYYSQY-IBGZPJMESA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 259133
Affinity DataKi: 15.4nM ΔG°: -10.8kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
Affinity DataKi: <20nM ΔG°: <-10.7kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair