BDBM259272 US9499547, 13

SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key InChIKey=CMDIADSAZCFCCT-LLVKDONJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 259272   

LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant MNK1 by measuring phosphorylation of biotinylated peptide TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50:  34nMpH: 7.5 T: 2°CAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In DepthDetails US Patent