BDBM261607 US10513499, Compound 18::US11254644, Compound 18::US9708272, 18

SMILES OC(=O)Cc1cccc(CSc2nc(-c3cccs3)c(C#N)c(=O)[nH]2)c1

InChI Key InChIKey=RJQYGCGMQYVVIB-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 261607   

Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

US Patent
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50:  10nMAssay Description:The pre-assay mixture consisting of 3-hydroxyanthranilic acid (3OH-HA), 3-hydroxyanthranilic acid, 3,4-diOxygenase (HAO), and a dialyzed crude extrac...More data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

US Patent
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

US Patent
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50:  10nMAssay Description:The activity of compounds 1-19 and 21-23 as inhibitors of ACMSD1 was determined by measuring the conversion of 3OH-Anthranilic Acid into product (i.e...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A1(Rattus norvegicus (rat))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant rat CYP3A1 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

US Patent
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50:  10nMAssay Description:The pre-assay mixture consisting of 3-hydroxyanthranilic acid (30H-HA), 3-hydroxyanthranilic acid, 3,4-diOxygenase (HAO), and a dialyzed crude extrac...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed