BDBM26280 2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-nitrophenyl)acetamide::pyrazoloquinazoline deriv., 14

SMILES COc1cc2c(Nc3cc(CC(=O)Nc4cccc(c4)[N+]([O-])=O)n[nH]3)ncnc2cc1OCCCN1CCC(CO)CC1

InChI Key InChIKey=PJXJTLKNCJRPQT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26280   

TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26280(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  39nM ΔG°:  -10.0kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26280(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  890nM ΔG°:  -8.25kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed