BDBM264206 (2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 27::US10654835, Example 27::US11247983, Example 27::US9714236, 27

SMILES COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1

InChI Key

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 264206   

TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM264206((2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{...)
Affinity DataIC50: >3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM264206((2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{...)
Affinity DataIC50:  575nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM264206((2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{...)
Affinity DataIC50: >3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent