BDBM267135 N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]-2,3-dimethoxybenzamide::US10167281, Compound 21::US9718812, 21

SMILES COc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cncs2)c1OC

InChI Key InChIKey=OCOBDDFDKXAENR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267135   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267135(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50:  31nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267135(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50:  129nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267135(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50:  31nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267135(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Affinity DataIC50:  129nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent