BDBM267171 N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluoropiperidin-1-yl)ethyl]-2-fluoro-5-(5-fluoropyrimidin-2-yl)benzamide::US10167281, Compound 106::US9718812, 106

SMILES Fc1cnc(nc1)-c1ccc(F)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(s1)C1CCC1

InChI Key InChIKey=NPACGBPEEZWPRQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 267171   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50:  1.24E+3nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50:  807nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50:  807nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50:  1.24E+3nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50:  42nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267171(N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluo...)
Affinity DataIC50:  114nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent