BDBM267190 N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]-2-(morpholin-4-yl)ethyl}quinoline-6-carboxamide::US10167281, Compound 115::US9718812, 115

SMILES FC1(F)CCC(CC1)c1ncc(s1)C(CNC(=O)c1cccc2ncccc12)N1CCOCC1

InChI Key InChIKey=VNKMAMKPIJLLQF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267190   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267190(N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]...)
Affinity DataIC50:  117nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267190(N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]...)
Affinity DataIC50:  32nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267190(N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]...)
Affinity DataIC50:  117nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267190(N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]...)
Affinity DataIC50:  32nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent