BDBM26740 N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide::PF-750

SMILES O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1

InChI Key InChIKey=BIODYGOZWZNCAG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 26740   

TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  33nMAssay Description:Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  1.09E+3nMAssay Description:Irreversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins before substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  595nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  248nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  16.2nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  16.2nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  595nMAssay Description:Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21-AI preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26740(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Affinity DataIC50:  51.9nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed