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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM26740
Substrate
BDBM23028
Meas. Tech.
FAAH Inhibition Assay (5 min Preincubation)
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
595±n/a nM
Comments
time-dependent inhibition.
Citation
 Ahn, K; Johnson, DS; Fitzgerald, LR; Liimatta, M; Arendse, A; Stevenson, T; Lund, ET; Nugent, RA; Nomanbhoy, TK; Alexander, JP; Cravatt, BF Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46:13019-30 (2007) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM26740
Synonyms:
N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide | PF-750
Type:
Small organic molecule
Emp. Form.:
C22H23N3O
Mol. Mass.:
345.4375
SMILES:
O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23028
Synonyms:
(9Z)-octadec-9-enamide | 14C-labeled oleamide | CHEMBL15927 | Oleamide | Oleic acid amide | Oleylamide
Type:
n/a
Emp. Form.:
C18H35NO
Mol. Mass.:
281.4766
SMILES:
CCCCCCCC\C=C/CCCCCCCC(N)=O
Structure:
Search PDB for entries with ligand similarity: