BDBM272571 US10065963, Compound 32a::US10376513, Example 345::US10646492, Example 346::US10675284, Example 32a::US9932341, Example 345

SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=ZQPDJCIXJHUERQ-MNOVXSKESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 272571   

LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50:  32nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50:  125nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50:  125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50:  125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50: <10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50:  125nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In DepthDetails US Patent