BDBM274860 2,6-Difluoro-N-(6-(2- (4-fluorophenyl)-6,7- dihydro-5H-pyrrolo [1,2-a]imidazol-3- yl)imidazo[1,2- b]pyridazin-2- yl)isonicotinamide::US9556179, Compound 437

SMILES Fc1ccc(cc1)-c1nc2CCCn2c1-c1ccc2nc(NC(=O)c3cc(F)nc(F)c3)cn2n1

InChI Key InChIKey=CIRPYCANFTVMBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274860   

TargetCasein kinase I isoform delta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274860(2,6-Difluoro-N-(6-(2- (4-fluorophenyl)-6,7- dihydr...)
Affinity DataIC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274860(2,6-Difluoro-N-(6-(2- (4-fluorophenyl)-6,7- dihydr...)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent