BDBM274880 N-(6-(2-(4- Fluorophenyl)-5,6,7,8- tetrahydroimidazo [1,2-a]pyrazin-3- yl)imidazo[1,2-b] pyridazin-2-yl)-2- morpholinoisonicotinamide::US9556179, Compound 458

SMILES Fc1ccc(cc1)-c1nc2CNCCn2c1-c1ccc2nc(NC(=O)c3ccnc(c3)N3CCOCC3)cn2n1

InChI Key InChIKey=VHPFTFCUQBEKML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274880   

TargetCasein kinase I isoform delta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274880(N-(6-(2-(4- Fluorophenyl)-5,6,7,8- tetrahydroimida...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274880(N-(6-(2-(4- Fluorophenyl)-5,6,7,8- tetrahydroimida...)
Affinity DataIC50:  3.70nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent