BDBM274901 2-Fluoro-N-(6-(2-(4- fluorophenyl)-7-(oxetan- 3-yl)-5,6,7,8- tetrahydroimidazo[1,2-a]pyrazin- 3-yl)imidazo[1,2-b]pyridazin-2- yl)isonicotinamide::US9556179, Compound 479

SMILES Fc1ccc(cc1)-c1nc2CN(CCn2c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)C1COC1

InChI Key InChIKey=YDYAXYYZKAPJIV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274901   

TargetCasein kinase I isoform delta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274901(2-Fluoro-N-(6-(2-(4- fluorophenyl)-7-(oxetan- 3-yl...)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274901(2-Fluoro-N-(6-(2-(4- fluorophenyl)-7-(oxetan- 3-yl...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent