BDBM275784 5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)oxy)-N-(N,N- dimethylsulfamoyl)- 2-fluorobenzamide::US10071957, Example 3

SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1Cl

InChI Key InChIKey=FPPKSWZDWMUMIR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 275784   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275784(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Affinity DataIC50:  11nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275784(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Affinity DataIC50:  24.8nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275784(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Affinity DataIC50:  2.18E+3nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent