BDBM275791 5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)-2-fluoro- N-(N-methyl- sulfamoyl)benzamide::US10071957, Example 8

SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F

InChI Key InChIKey=OYZAUKLTUHYZQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275791   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275791(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Affinity DataIC50:  109nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275791(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Affinity DataIC50:  22nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent