BDBM275792 N-(azetidin-1- ylsulfonyl)-5-chloro- 4-(4-chloro-3- (trifluoromethyl) phenoxy)-2- fluorobenzamide::US10071957, Example 9

SMILES Fc1cc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1

InChI Key InChIKey=KJDKNKAWFBQABR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275792   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275792(N-(azetidin-1- ylsulfonyl)-5-chloro- 4-(4-chloro-3...)
Affinity DataIC50:  80.7nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275792(N-(azetidin-1- ylsulfonyl)-5-chloro- 4-(4-chloro-3...)
Affinity DataIC50:  16nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent