BDBM275809 N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-chloro-6- isobutoxypyridin- 3-yl)oxy)-2- fluorobenzamide::US10071957, Example 26

SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl

InChI Key InChIKey=SYKGVYUTMUAYJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275809   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275809(N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...)
Affinity DataIC50:  77.3nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275809(N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...)
Affinity DataIC50:  9nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent