BDBM275821 5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- propoxy)pyridin- 3-yl)oxy)methyl)- N-(N,N-dimethyl- sulfamoyl)-2-fluoro- benzamide::US10071957, Example 39::US10071957, Example 76

SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F

InChI Key InChIKey=JWJGDFKYGVLSIF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 275821   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275821(5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...)
Affinity DataIC50:  216nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275821(5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...)
Affinity DataIC50:  220nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275821(5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...)
Affinity DataIC50:  34.3nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent