BDBM277358 (R or S)-tert-butyl 4-(3-(4- (1-(tert-butylamino)-2,2,2- trifluoroethyl)phenyl- amino)-4-oxo-4,5- dihydropyrazolo[4,3- c]pyridin-1-yl)-4- ethylpiperidine-1- carboxylate (Peak A, separated by HPLC, using ChiralpakAD-H column, eluting with 90% EtOH in hexanes, retention time: 14.5 minutes.)::US10072025, Example 2-36

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(cc2)[C@@H](NC(C)(C)C)C(F)(F)F)c2c1cc[nH]c2=O

InChI Key InChIKey=DTRJMDAVHUVYAE-HSZRJFAPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277358   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277358((R or S)-tert-butyl 4-(3-(4- (1-(tert-butylamino)-...)
Affinity DataIC50:  13nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277358((R or S)-tert-butyl 4-(3-(4- (1-(tert-butylamino)-...)
Affinity DataIC50:  8.43nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent