BDBM278038 2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-((S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile::US10040781, Example 260::US10253019, Example 260

SMILES C[C@H]1CN(CCN1c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C(=O)c3nnc[nH]3)c(c2)C#N)cc1)C1COC1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 278038   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278038(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Affinity DataIC50:  2.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278038(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Affinity DataIC50: <1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278038(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Affinity DataIC50:  42nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278038(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Affinity DataIC50:  2nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278038(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Affinity DataIC50: <1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278038(2-(((S)-3,3-difluoro-1-(4H-1,2,4-triazole-3-carbon...)
Affinity DataIC50:  4.20E+4nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent