BDBM278752 2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oct- 3-yl]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide::US10040798, Example 50::US10040798, Example 51

SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3C[C@H](C2)N3)c(n1)C(F)F

InChI Key InChIKey=BVBUDXSHAUSZPV-PHIMTYICSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278752   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278752(2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oc...)
Affinity DataIC50:  12nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278752(2-[(1S,5S)- or (1R,5R)- 3,6- diazabicyclo[3.2.1]oc...)
Affinity DataIC50:  4nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent