BDBM278799 N-(2-cyanothiophen-3- yl)-2-{[(1R,2S)-2- hydroxycyclohexyl] amino}pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 97

SMILES OC(=O)C(F)(F)F.O[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3ccsc3C#N)n2n1

InChI Key InChIKey=QNNNYKQHNSCBQF-CACIRBSMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278799   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278799(N-(2-cyanothiophen-3- yl)-2-{[(1R,2S)-2- hydroxycy...)
Affinity DataIC50:  1.37E+3nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent