BDBM279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77

SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=TZBBGNNWRKPAEH-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279047   

LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  64nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  21nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279047(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...)
Affinity DataIC50:  0.220nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent