BDBM279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81

SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=BVKDBZHCRMPMSA-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279050   

LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279050(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2...)
Affinity DataIC50:  0.260nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent